- Title
- Calprotectin, an emerging biomarker of interest in COVID-19: a systematic review and meta-analysis
- Creator
- Udeh, Raphael; Advani, Shailesh; de Guadiana Romualdo, Luis Garcia; Dolja-Gore, Xenia
- Relation
- Journal of Clinical Medicine Vol. 10, Issue 4, no. 775
- Publisher Link
- http://dx.doi.org/10.3390/jcm10040775
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2021
- Description
- COVID-19 has been shown to present with varied clinical course, necessitating a need for more specific diagnostic tools that could identify severe cases and predict outcomes during COVID-19 infection. Recent evidence has shown an expanded potential role for calprotectin, both as a diagnostic tool and also as a tool in stratifying COVID-19 patients in terms of severity. Therefore, this systematic review and meta-analysis aims to evaluate the levels of calprotectin in severe and non-severe COVID-19 and also identify the implication of raised calprotectin levels. MEDLINE, EMBASE, The Cochrane Library, Web of science and MedRxiv were searched. Meta-analysis was done to compare the serum/fecal levels of calprotectin between severe and non-severe COVID-19 infections. A total of ten studies included in the review (eight had quantitative data while two were qualitative). A pooled analysis of the eight studies from 613 patients who were RT-PCR positive for COVID-19 (average age = 55 years; 52% males) showed an overall estimate as 1.34 (95%CI: 0.77, 1.91). In conclusion, calprotectin levels have been demonstrated to be significantly elevated in COVID-19 patients who develop the severe form of the disease, and it also has prognostic importance.
- Subject
- COVID-19; calprotectin; biomarker; systematic review; meta-analysis; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1456376
- Identifier
- uon:45217
- Identifier
- ISSN:2077-0383
- Rights
- © This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Language
- eng
- Full Text
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